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Fluorescent Probe for Cancer Stem Cell-Specific Visualization
Useful for the simple and rapid detection of cancer stem cells present in various types of cancer by detecting both ALDH1A1 and ALDH1A3
Background
Cancer tissues contain cancer stem cells (CSCs) that exhibit resistance to anticancer drugs and metastasis. It is known that ALDH1A1 (1A1) and ALDH1A3 (1A3), which are aldehyde dehydrogenases, are expressed as biomarkers in CSCs. However, the currently available probes are unable to sensitively distinguish 1A3, making it difficult to detect CSCs in various cancers and to evaluate CSCs in metastatic cancers. Therefore, the development of probes that can sensitively respond to both 1A1 and 1A3 has been highly sought after.
Description and Advantages
The research team has developed a fluorescent probe that responds with high sensitivity to both 1A1 and 1A3. This allows for the distinction of expression differences between 1A1 and 1A3, enabling the easy detection of various CSCs.
➢ Useful for analyzing the primary site analysis of metastatic cancer
➢ Applicable for various types of CSCs due to the probe's responsiveness to 1A3
➢ Relatively easy synthesis process
| Development Status |
・Confirmed the luminescence intensity within CSCs (Fig.1) ・High emission intensity was observed when co-stained with green fluorescent probe ・Relatively easy to synthesize in a few short steps. |
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| Offer | • Patent License • Option for License • Collaborative Research • MTA for sample testing |
| Related Links | View PDF |
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- Fluorescent Probe for Cancer Stem Cell-Specific Visualization
3rd Floor, International Science
Innovation Building, Kyoto University
Yoshidahonmachi, Sakyo-ku, Kyoto
600-8501 JAPAN